My web application is not working on IE10

My web application is not working on IE10

My web application which was working fine till now (on server), suddenly
stopped working after IE is upgraded to IE10 version. It seems postback
code is not at all getting called and hence nothing is happening.
I tried Hotfix as suggested in many place
(http://support.microsoft.com/kb/2600088) but it has no effect. Also i
tried creating App_Browsers folder in my application and adding the
browser definition files manually there but to no effect.
Same application is working fine in my development machine with IE 10 ,
but not on production server.
Guys please advice what could be wrong and why this hotfix has not worked
for me. Also what can i try to make this application working.
Regards, Arpan